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DNA Damage Response
DNA is a building block for entire the genome and encodes genetic codes, which determine almost every aspect of life. In some cases DNA could be damaged by endogenous asserts such as replication errors and oxidation stresses or exogenous challenges such as radiation or toxic chemicals.
A novel chemotherapeutic agent to treat tumors with DNA mismatch repair deficiencies Yongliang Zhang, Jennifer T Fox, Young-Un Park, Gene Elliott, Ganesha Rai, Mengli Cai, Srilatha Sakamur...
HLTF and SHPRH are not essential for PCNA polyubiquitination, survival and somatic hypermutat... Lee, K. Y.*, Krijger, P.*, Wit, N., Berk, P., Wu, X., Roest, H. P., Maas, A., Hao Ding, H., Hoeijmakers...